Therapeutic Proteins Production Service
Therapeutic proteins are the exogenous proteins and used for the treatment or prevention of many difficult miscellaneous disease in humans or animals. Based on molecular types, therapeutic proteins can be divided into antibody-based drugs, Fc fusion proteins, anticoagulants, blood factors, bone morphogenetic proteins, engineered protein scaffolds, enzymes, growth factors, hormones, interferons, interleukins, and thrombolytics.
Since the approval of insulin in 1982, recombinant proteins have gained increasing importance for therapeutic applications.The most promising therapeutic recombinant proteins are monoclonal antibodies (mAbs) originally replicated from human immunoglobulin G1 (IgG1) with high specificity as the target epitope.
Figure 1 The therapeutic protein defined by the process (Dingermann, T. 2008)
Therapeutic proteins are expressed in a production organism. Currently, the most utilized expression systems are Chinese Hamster Ovary (CHO) cells and Escherichia coli. About 60% percent recombinant therapeutic proteins are produced in mammalian cells, mainly because of the ability to generate high-quality proteins similar in biochemical properties to naturally human forms. This growing demand for high-quality recombinant therapeutics is driving the research and development of proteins production systems for enhanced yields.
Fundamental Issues Must Be Considered When Choosing the Expression System:
- Protein size
- Folding and solubility
- Post-translational modification
- Safety
- Genetic engineering
- Maximum yield
- Growth conditions and rate
Recombinant Therapeutic Proteins Production System Offered by Creative BioMart Microbe:
- Expression in bacterial
- Expression in Yeast or filamentous fungi
- Expression in insect cells
- Expression in mammalian cells
- Expression in whole animal
- Expression in plant expression systems
Creative BioMart Microbe is keen to communicate and cooperate with our clients on therapeutic proteins production related services. With hundreds of recombinant proteins expression experience, we can offer you complete and custom projects service. Please feel free to contact us for a quote.
References:
- Burnett, Matthew J. B.; Burnett, Angela C. Therapeutic recombinant protein production in plants: Challenges and opportunities. Plants, People, Planet. 2019, ppp3.10073.
- Dingermann, T. Recombinant therapeutic proteins: Production platforms and challenges. Biotechnology Journal. 2008, 3(1): 90–97.
