Fermentation Process Scale-Up Services
In most industrial fermentations, biological or eukaryotic cells are immersed in a liquid medium. Scaling up is an important factor in industrial fermentation, which is an important process for converting laboratory procedures to industry. Scale up process are studies carried out at the laboratory or even pilot plant scale fermenters to yield data that could be used to extrapolate and build the large scale industrial fermenters with sufficient confidence it will function properly with all its behaviors anticipated.
During scale up process，Creative BioMart Microbe are trying to build industrial size fermenters capable or close of producing the fermentation products as efficient as those produced in small scale fermenters.
Creative BioMart Microbe’s fermentation scale-up laboratory mainly carry out metabolite scale up studies services through optimization the following points:
- Inoculum development
- Establishing the correct sterilization cycle at larger loads
- Environment parameters including nutrient availability, pH, temperature, dissolved oxygen and dissolved carbon dioxide.
Creative BioMart Microbe’s fermentation scale-up laboratory and optimization laboratory make joint efforts to solve the key technology and problems of the fermentation process optimization and control, in order to obtain high yield, high substrate conversion rate and high production strength relatively unified as the goal, from optimization of microbial genes, regulating intracellular microenvironment and optimize the macro environment, the development of the comprehensive consideration biology, kinetics and physics phenomenon of the fermentation process optimization technology to meet the market demand and research needs.
Why Choose Creative BioMart Microbe? What Do We Have About Our Fermentation Platform?
Full Staffing
- We have researchers from the field of fermentation engineering and microbiology, who can develop and optimize the whole fermentation process
- Have operators engaged in fermentation industry for many years, familiar with the operation of fermentation tank and various analytical equipment
- Have a professional QC team, able to abide by the FDA terms and conditions and other documents and technical documentation
- Have a timely technical support and customer service team, can real-time technical communication with customers, tracking services.
High Quality Fermentation Equipment
- Large scale fermenter, pilot scale fermenter and experimental fermenters
- Hollow fiber filtration system
- Frozen centrifuge
A Variety of Expression Systems
We have a variety of expression systems, including E. coli expression system, Bacillus subtilis expression system, Pichia pastoris expression system, Saccharomyces cerevisiae expression system, etc.
Many Years of Experience in Scale-Up
Creative BioMart Microbe has many years of experience in fermentation process scale-up services and can meet the needs of different customers.
Guidelines for scaling from a pilot-plant bioreactor to a commercial plant reactor Creative BioMart Microbe follow (according to Fogler & Gurmen, University of Michigan):
- Choose fermenter volume required based on desired capacity
- Choose impeller diameter
- Calculate reactor dimension based on geometric similarity, with the impeller diameter being the characteristic length
- Calculate impeller speed
- Choose mass transfer correlation
- Calculate gas flow rate using the correlation and setting
- Calculate power requirement
For the product development process, scale-up process until the final commercial production, we can provide customers with fermentation technology support. Confidentiality agreements signed by Creative BioMart Microbe and our staff will protect all of your technology. Test information will only be provided to employees who need to know at Creative BioMart Microbe.
Creative BioMart Microbe is an international company with international customers, whose trust and respect are vital to our technology and product sales. We will do our best to protect your technology and commercialize it for you. If you want to know more test information and price information, please feel free to contact us and we will reply to you as soon as possible.
