Antibiotic-Producing Microorganisms Service

Antibiotics have been critical in the healthcare system since the discovery and large-scale clinical application of penicillin. The sources of antibiotics include microorganisms, plants and chemical synthesis, and the secondary metabolites of microorganisms are the source of many antibiotic drugs. Soil is a complex environment suitable for the survival of microbial communities, containing a large number of different types of microorganisms. Most of the antibiotics discovered each year are obtained from soil. The secondary metabolites of microorganisms are an important source of antibiotics, and more than 80% of the antibiotics used clinically are derived from the metabolites of microorganisms isolated from soil. These antibiotics are very effective against infections and disease-causing microorganisms.

Figure 1. Mechanism of action of antibiotics. (Chandra, et al. 2017)

Actinomycetes are the main antibiotic-producing bacteria, and about 70% of natural antibiotics are isolated from the metabolites of actinomycetes, including actinomycin, tetracycline, chloramphenicol, vancomycin, gentamycin, etc. Pseudomonas, Bacillus species and filamentous fungi are also common antibiotic-producing microorganisms.

Natural microbial metabolites are still an effective means of discovering new antibiotic drugs. By analyzing soils in different ecosystems and biogeographic regions, novel antimicrobial strains with novel modes of action and secondary metabolites can be discovered. Creative BioMart Microbe provides a one-stop antibiotic-producing microorganism research service platform, including strain isolation and screening, antibiotic analysis, strain identification and characterization, etc., to provide customers with comprehensive solutions for antibiotic-producing microorganisms.

Test Microorganisms

• Staphylococcus aureus
• Bacillus subtilis
• Escherichia coli
• Pseudomonas aeruginosa
• Klebsiella pneumoniae
• Bacillus thuringiensis
• Proteus vulgaris
• Enterococcus faecalis
• Salmonella typhi
• Candida albicans
• Other more test microorganisms

Antibiotic-Producing Microorganisms Services

• Strain isolation and purification: Purified isolates were obtained from soil samples.
• Antibacterial screening: The obtained isolates were screened for microorganisms that showed clear inhibition of the test microorganisms.
• Antimicrobial compound production assay: Analysis of antimicrobial metabolite secretion capacity in antibiotic producing strains.
• Antimicrobial compound characterization: Analysis of antimicrobial metabolites for potency and stability, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) determinations.
• Bacterial and fungal identification & phylogenetic characterization.

Why Choose Creative BioMart Microbe?

• Antibiotic-producing microorganisms isolation, screening, identification, as well as antibacterial compound characterization and other services to achieve comprehensive research on antibiotic-producing microorganisms.
• An experienced technical team ensures high accuracy and reproducibility of test results.
• Real-time technical communication and tracking services.
• Competitive test prices.

Workflow of Plant Pathogen Detection Service in Creative BioMart Microbe

If you want to know more information about this service, please feel free to contact us by phone or email, or you can consult through our inquiry form. We will ensure to provide you with efficient and high-quality experimental outsourcing services.

References:

1. Bano, S. A., et al. Detection of microorganisms with antibacterial activities from different industrial wastes and GC-MS analysis of crude microbial extract. Brazilian Journal of Biology. 2021, 83.
2. Chandra, N., Kumar, S. Antibiotics Producing Soil Microorganisms. Hashmi, M.Z., et al. (eds), Antibiotics and Antibiotics Resistance Genes in Soils. Soil Biology. 2017, 51. Springer, Cham.