In recent years, important progress has been made in the study of intestinal flora in the signal transduction pathway of fat metabolism and inflammation pathway. At present, a variety of human flora associated (HFA) animal models have been reported, which is conducive to the direct study of the relationship between intestinal flora of patients and diseases (especially obesity).
The establishment of non-bacterialized animal models (such as HFA animal models) carrying human flora has provided a better model for studying the ecosystem and metabolism of human intestinal flora. Creative BioMart Microbe can provide HFA mice model for the majority of hospitals and research institutions.
Through the fecal flora transplantation method, the human intestinal flora is "placed" on the mouse model to prepare the humanized mouse model, and the evaluation can be carried out, which can simulate some human diseases.
Our scientists will provide suggestions on the construction of different HFA mouse models according to different real situations of customers. The HFA mouse model service provided by Creative BioMart Microbe has the following advantages:
HFA mice partially simulated the microbiome of patients with a disease such as obesity, and mice of the same sex as the patient did better. The HFA mouse model established by our company provides a new choice for the further study of the relationship between diseases (such as obesity) and intestinal flora.
Creative BioMart Microbe is able to construct a HFA animal model by selecting sterile mice and inoculating the feces of obese patients, and denatured gradient gel electrophoresis (DGGE) was used to evaluate the colonization of intestinal flora of patients in sterile mice.
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