High-throughput Screening Accelerates Drug and Molecule Development

Developing a new drug to the finished product is a complex process often spanning more than ten years. High-throughput screening (HTS) has been adopted into technology and process improvements to increase efficiency and ultimately, bring better drugs to the market faster.

The steps of HTS including target identification, reagent preparation, compound management, assay development and high-throughput library screening. HTS assays are used to screen different types of libraries, including genomics, combinatorial chemistry, protein and peptide libraries. The main goal of HTS technology is to accelerate drug discovery by screening large compound libraries at a certain rate by robots, detectors and software. With a typical HTS, it is possible to screen up to 10,000 compounds per day. Ultra High Throughput Screening (UHTS) can even perform 100,000 assays per day. In addition, HTS is also used to characterize metabolic, pharmacokinetic and toxicological data of new drugs.

Figure 1. General classification of HTS assays (Hasan, et al. 2021)

Advantages of Our HTS Service in Drug Development

• Comprehensive portfolio of assays.
• Wide range of technologies.
• Diversity kinds of libraries.
• Unique testing and selectivity methods.
• Best price and short turn-around time.

Creative BioMart Microbe is your best partner in drug and active molecule discovery program. With breadth of experience and vast access to scientific experts, we can provide a customizable solution that works to reduce your development timeline. Please feel free to contact us for more information.

References:

1. Szymański, P.; et al. Adaptation of High-Throughput Screening in Drug Discovery—Toxicological Screening Tests. International Journal of Molecular Sciences. 2011, 13(1): 427–452.
2. Hasan A.; et al. High-Throughput Screening Platforms in the Discovery of Novel Drugs for Neurodegenerative Diseases. Bioengineering (Basel). 2021, 8(2): 30.