Microbial Fermentation Service for Bio-Pharmaceuticals

Bio-pharmaceuticals are mostly therapeutic recombinant proteins produced by bio-technological processes. Currently, microbial fermentation is the main technology to gain mass production of potential active pharmaceutical ingredients (APIs), including therapeutic proteins, enzymes, hormones, metabolites, blood substitutes and vaccines.

Microbial fermentation process uses various microorganisms to convert raw materials into useful products. Microorganisms used in fermentation include, bacteria, algae, fungi, and actinomycetes. For small and low-weight molecules, like peptides, proteins, carbohydrates, lipids and non-glycosylated fragments, microbial fermentation in bacterial, yeast or filamentous fungi is the preferred production method. This short and cost-efficient process can produce large quantities in desired bio-pharmaceuticals.

Figure 1. Upstream and downstream process in bio-pharmaceutical manufacturing (Jozala, A.F., et al. 2016)

Generally, the fermentation process can be grouped into two types, one is the batch/fed-batch, and another is the continuous/semi-continuous process. As a leading microbial fermentation services for bio-pharmaceuticals provider, Creative BioMart Microbe has extensive experience with microbial processes using advanced engineering and process development capabilities.

Microbial Fermentation Steps in Creative BioMart Microbe

Strain selection and optimization
Media and process development
Fermentation and scale up
Downstream processing

Features of Microbial Fermentation Service in Creative BioMart Microbe

Fully instrument and process
In place cleaning and sanitization
Industrial scale and analytics
Customized projects and services

Microbial Fermentation Services for Bio-Pharmaceuticals

The bio-pharmaceuticals development is very dynamic; we adjust plans based on teamwork with our customers to define a tailored solution for each project. Please feel free to contact us for more information.

Reference:

Jozala, A. F., et al. Biopharmaceuticals from microorganisms: from production to purification. Brazilian Journal of Microbiology. 2016,, 47: 51-63.