Cat.No.
tcdB-007C
Species
C. difficile
Product Name
Recombinant C. difficile tcdB Protein
Product Overview
Recombinant Clostridioides difficile tcdB protein without tag was expressed in E.coli
Description
Toxin B from Clostridium difficile, also known as TcdB, is a cytotoxin that has glucosyltransferase and cysteine protease activities. It inactivates host Rho family GTPases by glucosylation, altering cytoskeletal structure, cell division, and cell-cell adhesion. Toxin B can induce activation of the inflammasome and apoptosis. While both toxin A and toxin B inactivate Rho family GTPases, toxin B more potently induces mammalian cell rounding in culture.
Source
E. coli
Purity
≥90% estimated by SDS-PAGE
Stability
≥ 2 years
Storage
2 to 8 centigrade
Concentration
0.2 mg/ml
Storage Buffer
Each vial contains 50 μg of C. difficile toxin B in 50 mM Tris, 100 mM NaCl, pH 7.5
Shipping
Room Temperature in continental US, may vary elsewhere.
Official Symbol
Synonyms
tcdB; glycosylating toxin TcdB; toxB; glycosylating toxin TcdB
Gene ID
UniProt ID
