Cat.No.
PT-141B
Species
Bordetella pertussis
Product Name
Native Bordetella pertussis Perrtussis toxin
Product Overview
This product was highly purified (>90% pure) from Bordetella pertussis strain Tohama. Cytotoxicity of the PT was confirmed by morphological alteration of CHO cells after treatment with 0.1 ng/ml of PT.
Description
Perrtussis toxin (PT) is a protein-based AB5-type exotoxin produced by Bordeterra pertussis. PT catalyzes the ADP-ribosylation of the α subunits of the heterotrimeric guanine nucleotide regulatory proteins Gi, Go, and Gt and prevents intracellular signal transduction involving the G proteins. PT consists of one moplecule of each S1 (26 kDa), S2 (22 kDa), S3 (22 kDa), S5 (12 kDa) and two molecule of S4 (12 kDa).
Source
Bordetella pertussis
Form
83 μg/ml in 10% glycerol 10 mM phoshate buffer (pH 7.4), 137 mM NaCl
Applications
1. Studies on the signal transduction of the trimeric GTP binding proteins. 2. Therapeutic role in treating a number of diseases including hypertention, viral and autoimumune inhibitions.
Storage
Store at -70℃
