Cat.No.
Lectin-1760A
Species
Agaricus bisporus
Product Name
Native Agaricus bisporus lectin Protein
Product Overview
This product is the unconjugated Agaricus bisporus lectin and has sugar specificity against Gal(b-1,3)GalNAc (T disaccharide).
Description
Agaricus bisporus lectin (ABL) isolated from the edible white button mushroom, is composed of two to four very similar isolectins, each a tetramer of approximately 17 kD subunits. This lectin binds the Thomsen-Friedenreich antigen, also called T disaccharide, galactosyl (β-1,3) N-acetylgalactosamine. Unlike peanut agglutinin, which does not bind sialylated T antigen, ABL binds either sialylated or asialylated forms. Also, whereas peanut agglutinin has a proliferative effect on cancer cells, ABL is anti-proliferative, apparently without cytotoxicity. ABL binds all blood groups and O-linked glycans of IgA subclasses. Simple mono- and disaccharides are only marginally inhibitory.
Source
Agaricus bisporus
Form
10 mM HEPES, pH 7.5, 150 mM NaCl, 0.08% sodium azide
Storage
Refrigerate in the dark.
Synonyms
Lectin; ABL
UniProt ID
Concentration
2 mg/ml
Bio-activity
Sugar Specificity: Gal(b-1,3)GalNAc (T disaccharide)
Applications
Immunofluorescence, Glycobiology
Application
Immunofluorescence, Glycobiology
